The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods

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Works under MDS Aspergillus in the genomic era by Janos Varga Aspergillus fumigatus : new insights for the healthcare professional : ScholarlyBrief by Q. Castrillo Yeast functional genomics and proteomics methods and protocols by Igor Stagljar. Wording Edition. What is MDS? LibraryThing's MDS system is based on the classification work of libraries around the world, whose assignments are not copyrightable.

My laboratory is conducting research aimed at elucidating how the cell cycle is regulated with focus on the regulation of mitosis, the universal mechanism by which our DNA is segregated equally to daughter cells during growth and development. These findings will provide insights into how mitosis is regulated in filamentous fungi , a poorly understood group of organisms which have far-reaching beneficial and detrimental impacts on mankind.


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The findings should also provide insights into how mitosis is regulated in higher eukaryotes with implications for how cancer develops and can be treated. Recent work in the lab has focused on understanding how nuclear transport is regulated during mitosis.

The Aspergilli

In higher eukaryotes the nuclear envelope is dismantled during mitosis open mitosis by ill-defined mechanisms. However in fungi, such as A. During closed mitosis, proteins such as tubulin which forms the mitotic spindle enter nuclei only during mitosis. It had long been assumed that specific transport pathways through nuclear pore complexes NPCs, the structures providing regulated conduits across the nuclear envelope between the cytoplasm and the nucleoplasm were modified during closed mitosis.

However, our recent findings have demonstrated that in A. The NPC proteins that remain form a core conduit between the inside and outside of nuclei.

The Anatomical Organization of the Suprasylvian Gyrus of the Cat Advances in Anatomy Embryology and

During exit from mitosis the dispersed NPC proteins return back to the core NPC structure and reestablish regulated transport. These findings provide a new paradigm for how mitosis can be regulated and indicate A. In addition to explaining how nuclear transport is regulated during A. The challenge now is to define which NPC proteins are phosphorylated then dephosphorylated to reversibly disassemble the NPC during mitosis. Also of interest is how proteins released from NPCs during mitosis play roles to facilitate mitotic progression and coordinate nuclear restructuring with successful high fidelity DNA segregation.

Graduate Students:. J Cell Biol. Fungal Genet Biol. Epub Mar Mol Biol Cell.

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Epub Jan 5. PLoS Genet. PLoS One. Eukaryotic Cell. Cell Cycle Volume 10 Issue De Souza, C. Hashmi, X.

Yang, and S. Markina-Inarrairaegui, A. Etxebeste, E. Herrero-Garcia, L. Araujo-Baza, J. Fernandez-Martinez, J. Flores, S. Osmani, and E.

Molecular Biology of the Cell. Cellular and Molecular Biology of Filamentous Fungi. ASM press, pp Liu, H. Osmani, L. Ukil, S. Son, S. Markossian, K. Shen, M. Govindaraghavan, A. Varadaraj, S. Hashmi, C. De Souza, and S. Eukaryotic cell. Nayak, T. Edgerton-Morgan, T. Horio, Y. Xiong, C. De Souza, S. Osmani, and B. The Journal of Cell Biology.

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